ARG44990
anti-ZFP36 / Tristetraprolin antibody
anti-ZFP36 / Tristetraprolin antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes ZFP36 / Tristetraprolin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | ZFP36 / Tristetraprolin |
| Antigen Species | Human |
| Epitope | DLAAPGHPPV LRQSISFSGL PSGRRTSPPP PGLAGPSLSS SSFSPSSSPP PPGDLPLSPS AFSAAPGTPL ARRDPTPVCC PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE AGVFAPPQPV |
| Conjugation | Un-conjugated |
| Alternate Names | ZFP36; ZFP36 Ring Finger Protein; RNF162A; NUP475; G0S24; TTP; Tristetraprolin; TIS11; Growth Factor-Inducible Nuclear Protein NUP475; MRNA Decay Activator Protein ZFP36; G0/G1 Switch Regulatory Protein24; Zfp-36; Zinc Finger Protein36, C3H Type, Homolog (Mouse); Zinc Finger Protein36, C3H Type, Homolog; Zinc Finger Protein36 Homolog; Zinc Finger Protein36; Tristetraproline; TIS11A; GOS24 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | ZFP36 |
|---|---|
| Gene Full Name | ZFP36 Ring Finger Protein |
| Background | Enables several functions, including14-3-3 protein binding activity; heat shock protein binding activity; and mRNA3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to growth factor stimulus; and regulation of gene expression. Acts upstream of or within mRNA catabolic process. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Part of ribonucleoprotein complex. Colocalizes with RISC-loading complex. [provided by Alliance of Genome Resources, Apr2022] |
| Function | Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells. [Uniprot] |
| Cellular Localization | Cytoplasm, Exosome, Nucleus. [Uniprot] |
| PTM | Phosphoprotein, Ubl conjugation. [Uniprot] |
