ARG41190
anti-ZFYVE9 antibody
anti-ZFYVE9 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ZFYVE9 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ZFYVE9 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-260 of Human ZFYVE9 (NP_004790.2). |
| Conjugation | Un-conjugated |
| Alternate Names | Smad anchor for receptor activation; Madh-interacting protein; SMADIP; PPP1R173; SARA; hSARA; Mothers against decapentaplegic homolog-interacting protein; MADHIP; Zinc finger FYVE domain-containing protein 9; NSP; Novel serine protease; Receptor activation anchor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HeLa | ||||
| Observed Size | 156 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O95405 Human Zinc finger FYVE domain-containing protein 9 |
|---|---|
| Gene Symbol | ZFYVE9 |
| Gene Full Name | zinc finger, FYVE domain containing 9 |
| Background | This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
| Function | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. [UniProt] |
| Cellular Localization | Cytoplasm. Early endosome membrane. [UniProt] |
| Calculated MW | 156 kDa |
