ARG55854
anti-ZRSR2 antibody
anti-ZRSR2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ZRSR2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ZRSR2 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 453-482 (C-terminus) of Human ZRSR2. |
| Conjugation | Un-conjugated |
| Alternate Names | Renal carcinoma antigen NY-REN-20; RNU2; CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2; U2AF35-related protein; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; U2; U2AF1L2; ZC3H22; URP; U2AF1RS2; U2AF1-RS2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HepG2 |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q15696 Human U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related |
|---|---|
| Gene Symbol | ZRSR2 |
| Gene Full Name | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 |
| Background | This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008] |
| Function | Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. [UniProt] |
| Cellular Localization | Nucleus. |
| Calculated MW | 58 kDa |
| PTM | Phosphorylated in the RS domain by SRPK1. |
