ARG58071

anti-alpha 1 Antichymotrypsin antibody

anti-alpha 1 Antichymotrypsin antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes alpha 1 Antichymotrypsin
Tested Reactivity Hu, Ms, Rat
Tested Application ICC/IF, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name alpha 1 Antichymotrypsin
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 24-423 of Human alpha 1 Antichymotrypsin (NP_001076.2).
Conjugation Un-conjugated
Alternate Names GIG24; GIG25; Cell growth-inhibiting gene 24/25 protein; Alpha-1-antichymotrypsin; ACT; Serpin A3; AACT

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:100
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse testis
Observed Size ~ 47 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 12 Human SERPINA3

Swiss-port # P01011 Human Alpha-1-antichymotrypsin

Gene Symbol SERPINA3
Gene Full Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Background The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
Function Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. [UniProt]
Cellular Localization Secreted. [UniProt]
Calculated MW 48 kDa
PTM N- and O-glycosylated. [UniProt]