ARG40584
anti-beta 2 Microglobulin antibody
anti-beta 2 Microglobulin antibody for Western blot,ICC/IF,Immunoprecipitation and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes beta 2 Microglobulin |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | beta 2 Microglobulin |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human beta 2 Microglobulin. |
| Conjugation | Un-conjugated |
| Alternate Names | Beta-2-microglobulin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | B2M |
| Gene Full Name | beta-2-microglobulin |
| Background | This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014] |
| Function | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [UniProt] |
| Cellular Localization | Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). Note=(Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553). [UniProt] |
| Calculated MW | 14 kDa |
| PTM | Glycation of Ile-21 is observed in long-term hemodialysis patients. [UniProt] |
