ARG58948
anti-n Myc antibody
anti-n Myc antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes n Myc |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | n Myc |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human n Myc. |
| Conjugation | Un-conjugated |
| Alternate Names | NMYC; bHLHe37; MODED; Class E basic helix-loop-helix protein 37; N-myc; N-myc proto-oncogene protein; ODED |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | SH-SY5Y | ||||||||
| Observed Size | 45 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MYCN |
| Gene Full Name | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog |
| Background | This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
| Function | Positively regulates the transcription of NCYM in neuroblastoma cells. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 50 kDa |
| PTM | Phosphorylated by GSK3-beta which may promote its degradation. [UniProt] |
