ARG54654

anti-p53DINP1 antibody

anti-p53DINP1 antibody for ELISA,Immunohistochemistry,Western blot and Human,Mouse,Rat

Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes p53DINP1
Tested Reactivity Hu, Ms, Rat
Tested Application ELISA, IHC, WB
Specificity At least two isoforms of p53DINP1 are known to exist; this antibody will detect both isoforms.
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name p53DINP1
Immunogen Synthetic peptide (14 aa) within the first 50 aa of Human p53DINP1.
Conjugation Un-conjugated
Alternate Names TP53DINP1; SIP; p53DINP1; Teap; Stress-induced protein; Tumor protein p53-inducible nuclear protein 1; p53-dependent damage-inducible nuclear protein 1; TP53INP1A; TP53INP1B

Application Instructions

Application Suggestion
Tested Application Dilution
ELISAAssay-Dependent
IHC2 μg/mL
WB0.5 - 1 μg/mL
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Human Lung Tissue Lysate
Observed Size 30 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 297822 Rat TP53INP1

GeneID: 94241 Human TP53INP1

Swiss-port # Q80YE2 Rat Tumor protein p53-inducible nuclear protein 1

Swiss-port # Q96A56 Human Tumor protein p53-inducible nuclear protein 1

Gene Symbol TP53INP1 
Gene Full Name tumor protein p53 inducible nuclear protein 1
Background p53DINP1 Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein 1) and SIP (for stress induced protein) in human and mouse. A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks. p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-alpha and p53DINP1-beta or SIP27 and SIP18. p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress. |
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody
Calculated MW 18, 27 kDa