ARG54563
anti-vWF antibody [VW92-3]
anti-vWF antibody [VW92-3] for Indirect ELISA,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody
Overview
| Product Description | Mouse Monoclonal antibody [VW92-3] recognizes vWF |
|---|---|
| Tested Reactivity | Hu |
| Species Does Not React With | Cow |
| Tested Application | I-ELISA, IHC-Fr, IHC-P, WB |
| Specificity | This antibody specifically recognizes human von Willebrand Factor V8 Protease Fragment III (N-terminal trypsin and plasmin sensitive region). This antibody does not inhibit the binding of vWF to the vitronectin receptor. This antibody does not react with bovine vWF. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | VW92-3 |
| Isotype | IgG2a |
| Target Name | vWF |
| Antigen Species | Human |
| Immunogen | Human plasma von Willebrand Factor. |
| Epitope | V8 Protease Fragment III; N-termini Trypsin and Plasmin sensitive region. |
| Conjugation | Un-conjugated |
| Alternate Names | VWD; von Willebrand factor; vWF; von Willebrand antigen II; F8VWF |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 10mM PBS (pH 7.4), 1% BSA |
| Stabilizer | 1% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | VWF |
| Gene Full Name | von Willebrand factor |
| Background | The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] |
| Function | Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. [UniProt] |
| Cellular Localization | Secreted |
| Highlight | VWF (Von Willebrand Factor) is a Protein Coding gene. Diseases associated with VWF include von willebrand's disease and von willebrand disease, type 1. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and protein N-terminus binding. An important paralog of this gene is OTOGL. [Supplied by GeneCards] |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody |
| Calculated MW | 309 kDa |
| PTM | All cysteine residues are involved in intrachain or interchain disulfide bonds. N- and O-glycosylated. |
