ARG57075
anti-CDC37 antibody [3G7]
anti-CDC37 antibody [3G7] for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [3G7] recognizes CDC37 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 3G7 |
| Isotype | IgG1, kappa |
| Target Name | CDC37 |
| Antigen Species | Human |
| Immunogen | Recombinant fragment around aa. 1-378 of Human Cdc37. |
| Conjugation | Un-conjugated |
| Alternate Names | p50Cdc37; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; P50CDC37 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 10% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CDC37 |
| Gene Full Name | cell division cycle 37 |
| Background | The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008] |
| Function | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. [UniProt] |
| Calculated MW | 44 kDa |
| PTM | Constitutively sumoylated by UBE2I. |
Images (1) Click the Picture to Zoom In
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ARG57075 anti-CDC37 antibody [3G7] WB image
Western blot: 40 µg of 1) Jurkat cell lysate, 2) A431 cell lysate, 3) K562 cell lysate, 4) LnCap cell lysate, 5) SW480 cell lysate, 6) HeLa cell lysate, 7) MCF7 cell lysate, 8) 293T cell lysate stained with ARG57075 anti-CDC37 antibody [3G7] at 1:1000.
