ARG55057
anti-CDC5L antibody
anti-CDC5L antibody for Western blot and Human,Mouse
Gene Regulation antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CDC5L |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CDC5L |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human CDC5L (Swiss: Q99459) |
| Conjugation | Un-conjugated |
| Alternate Names | Cell division cycle 5-like protein; dJ319D22.1; PCDC5RP; Pombe cdc5-related protein; CEF1; CDC5-LIKE; Cdc5-like protein; CDC5 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse testis and SW480 |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6A068 Mouse Cell division cycle 5-like protein Swiss-port # Q99459 Human Cell division cycle 5-like protein |
|---|---|
| Gene Symbol | CDC5L |
| Gene Full Name | cell division cycle 5-like |
| Background | The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008] |
| Function | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). [UniProt] |
| Research Area | Gene Regulation antibody |
| Calculated MW | 92 kDa |
| PTM | Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8. |
Images (1) Click the Picture to Zoom In
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ARG55057 anti-CDC5L antibody WB image
Western blot: Mouse testis and SW480 cell lysate stained with ARG55057 anti-CDC5L antibody.
