ARG40785
anti-Cannabinoid Receptor 2 antibody
anti-Cannabinoid Receptor 2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Cannabinoid Receptor 2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Cannabinoid Receptor 2 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 329-356 of Human Cannabinoid Receptor 2. |
| Conjugation | Un-conjugated |
| Alternate Names | CB2; CB-2; Cannabinoid receptor 2; CX5; hCB2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide. |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CNR2 |
| Gene Full Name | cannabinoid receptor 2 (macrophage) |
| Background | The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008] |
| Function | Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. [UniProt] |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon. Note=Localizes to apical dendrite of pyramidal neurons. [UniProt] |
| Calculated MW | 40 kDa |
| PTM | Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG40785 anti-Cannabinoid Receptor 2 antibody FACS image
Flow Cytometry: Jurkat cells stained with ARG40785 anti-Cannabinoid Receptor 2 antibody at 1:25 dilution (right histogram) or isotype control antibody (left histogram), followed by incubation with Alexa Fluor® 488 labelled secondary antibody.
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ARG40785 anti-Cannabinoid Receptor 2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human skin carcinoma tissue stained with ARG40785 anti-Cannabinoid Receptor 2 antibody.
