ARG10779
anti-DRD2 / Dopamine Receptor D2 antibody
anti-DRD2 / Dopamine Receptor D2 antibody for ELISA,ICC/IF,IHC-Frozen sections,Immunoprecipitation,Western blot and Mouse,Rat
Publication1
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DRD2 / Dopamine Receptor D2 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | ELISA, ICC/IF, IHC-Fr, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DRD2 / Dopamine Receptor D2 |
| Antigen Species | Rat |
| Immunogen | Synthetic peptide taken within aa. 150-200 from Rat DRD2 / Dopamine D2 receptor. |
| Conjugation | Un-conjugated |
| Alternate Names | D2R; D2DR; D(2) dopamine receptor; Dopamine D2 receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 30% Glycerol and 0.5% BSA |
| Concentration | 0.75 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Drd2 |
| Gene Full Name | dopamine receptor D2 |
| Background | This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008] |
| Function | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. [UniProt] |
| Calculated MW | 51 kDa |
Images (3) Click the Picture to Zoom In
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ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody IHC-Fr image
Immunohistochemistry: Mouse brain stained with ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody.
From Nai-Li Wei et al. Neuropsychiatr Dis Treat. (2019), doi: 10.2147/NDT.S204818, Fig. S1.
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ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody WB image
Western blot: 1) Recombinant Dopamine D2 receptor protein, and 2) cerebellar membranes stained with ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody at 1:500 dilution.
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ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody WB image
Western blot: Rat striatal membranes stained with ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody at 1:500 dilution.
Specific References
Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens.
IHC-Fr / Mouse
