ARG58501
anti-DTNA / alpha dystrobrevin antibody
anti-DTNA / alpha dystrobrevin antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes DTNA / alpha dystrobrevin |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | DTNA / alpha dystrobrevin |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 240-480 of Human DTNA / alpha dystrobrevin (NP_001381.2). |
| Conjugation | Un-conjugated |
| Alternate Names | D18S892E; DTN; DRP3; Dystrobrevin alpha; Alpha-dystrobrevin; LVNC1; Dystrophin-related protein 3; DTN-A |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse brain | ||||
| Observed Size | ~ 80 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DTNA |
| Gene Full Name | dystrobrevin, alpha |
| Background | The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Function | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. [UniProt] |
| Cellular Localization | Cytoplasm, Cell junction, synapse, Cell membrane. [UniProt] |
| Calculated MW | 84 kDa |
| PTM | Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG58501 anti-DTNA / alpha dystrobrevin antibody WB image
Western blot: 25 µg of Mouse brain lysate stained with ARG58501 anti-DTNA / alpha dystrobrevin antibody at 1:3000 dilution.
