Overview

Product Description	Rabbit Polyclonal antibody recognizes ELP3 / KAT9
Tested Reactivity	Hu, Ms, Rat
Tested Application	ICC/IF, IP, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	ELP3 / KAT9
Antigen Species	Human
Immunogen	Synthetic peptide of Human ELP3 / KAT9.
Conjugation	Un-conjugated
Alternate Names	KAT9; Elongator complex protein 3; hELP3; EC 2.3.1.48

Application Instructions

Application Suggestion	Tested Application Dilution ICC/IF 1:50 - 1:200 IP 1:50 WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	HeLa
Observed Size	~ 62 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 55140 Human ELP3 GeneID: 74195 Mouse ELP3 Swiss-port # Q9CZX0 Mouse Elongator complex protein 3 Swiss-port # Q9H9T3 Human Elongator complex protein 3
Gene Symbol	ELP3
Gene Full Name	elongator acetyltransferase complex subunit 3
Background	ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]
Function	Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin. May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). [UniProt]
Cellular Localization	Cytoplasm. Isoform 1: Nucleus. Isoform 2: Cytoplasm. Nucleus. [UniProt]
Calculated MW	62 kDa

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