ARG58611
anti-PHC1 antibody
anti-PHC1 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PHC1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PHC1 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide between aa. 308-342 of Human PHC1. |
| Conjugation | Un-conjugated |
| Alternate Names | hPH1; RAE28; EDR1; Polyhomeotic-like protein 1; MCPH11; Early development regulatory protein 1; HPH1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Jurkat |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PHC1 |
| Gene Full Name | polyhomeotic homolog 1 (Drosophila) |
| Background | This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008] |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. [UniProt] |
| Calculated MW | 106 kDa |
Images (1) Click the Picture to Zoom In
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ARG58611 anti-PHC1 antibody WB image
Western blot: 20 µg of Jurkat cell lysate stained with ARG58611 anti-PHC1 antibody at 1:2000 dilution.
