ARG45123
anti-Patched 1 antibody
anti-Patched 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Chicken,Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Patched 1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Chk |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Patched 1 |
| Antigen Species | Mouse |
| Conjugation | Un-conjugated |
| Alternate Names | PTCH1; Patched 1; BCNS; PTCH; Protein Patched Homolog 1; NBCCS; PTC1; PTC; Patched Homolog 1 (Drosophila); Patched (Drosophila) Homolog; Patched Homolog (Drosophila); BCNS1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified |
| Buffer | PBS with 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PTCH1 |
| Gene Full Name | Patched 1 |
| Background | This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017] |
| Function | Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. [Uniprot] |
| Cellular Localization | Cell membrane; Membrane. [Uniprot] |
| Calculated MW | 161 kDa |
| PTM | Glycoprotein; Isopeptide bond; Phosphoprotein; Ubl conjugation. [Uniprot] |
