ARG30276

Cytochrome-C fractionation Antibody Panel (Cytochrome-C, COX IV, beta Actin)

publication_link Publication2

Component

Cat No Component Name Host clonality Reactivity Application Package
ARG62461 anti-Cytochrome C antibody [6H2.B4] Mouse mAb Hu, Ms, Rat FACS, ICC/IF, IP, WB 250 μl
ARG54003 anti-COX4 antibody Mouse mAb Goat, Hm, Hu, Mk, Ms, Rat FACS, ICC/IF, IHC-P, IP, WB 50 μl
ARG53987 anti-beta Actin antibody Mouse mAb Arabi, Chk, C. reinhardtii, Cucumber, Dm, Fsh, Goat, Hm, Hu, Mk, Ms, P. pastoris, Pig, Rb, Rat, Rice, S. cerevisiae, Yeast, Zfsh WB 50 μl
ARG65350 Goat anti-Mouse IgG antibody (HRP) Goat pAb Ms ELISA, IHC-P, WB 50 μl

Overview

Product Description

Apoptosis is a process of programmed cell death that occurs in multicellular organism. Intracellular or extracellular death signals kick-start apoptosis signaling by releasing Cytochrome-C from mitochondria through BAX. The released Cytochrome-C binds to APAF-1 and cleave caspase 9. Finally, caspase-3 and PARP will be cleaved and the cells officially go into apoptosis and die. The cellular localization of Cytochrome-C often informs us of the trigger of apoptosis pathway. Hence, Cytochrome-C antibody together with COX IV (mitochondria marker) and beta Actin (cytoplasm marker) antibodies form a great package for the study of Cytochrome-C localization through cell fractionation.

Nur-E-Lamal et al. 2004. JBC 279:24911-24914

Target Name Cytochrome-C fractionation
Alternate Names Cytochrome-C fractionation antibody; beta Actin antibody; COX4 antibody; Cytochrome C antibody

Properties

Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Specific References

KDF1 Promoted Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells through Activating STAT3 and AKT Pathway

ARG65350: WB / 

Yi-Qing Guo et al.
Biomedicines.,  (2023)

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Morphofunctional analysis of fibroblast-like synoviocytes in human rheumatoid arthritis and mouse collagen-induced arthritis

ARG53987: WB / Human

Camilla Ribeiro Lima Machado et al.
Adv Rheumatol.,  (2023)

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