ARG30273
LC3A and LC3B Antibody Duo
Publication5
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51300 | anti-LC3A antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG55799 | anti-LC3B antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
Overview
| Product Description | Autophagy consists of a destructive mechanism that disassemble unnecessary or dysfunctional cellular components through a regulated process. Targeted cellular constituents are enclosed by double-membraned vesicle called autophagosome. LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. They are processed from their precursors and bound to PE to form autophagosome before being fused to lysosome and breakdown the enclosed components. In the cytoplasm, there was a minimal co-localization between LC3A and B staining, suggesting that the relevant autophagosomes are formed by only one out of the two LC3 proteins. Koukourakis M. et al. 2015. Plos One 17(10) Related news: Keap1-Nrf2-ARE antibody panel is launched Freeze! Scientists found a way to stop tumor migration Therapeutic strategies against PDAC |
|---|---|
| Target Name | LC3A and LC3B |
| Alternate Names | LC3A and LC3B antibody; Microtubule-associated protein 1 light chain 3 alpha and Microtubule-associated protein 1 light chain 3 beta antibody; LC3A antibody; LC3B antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Microtubule-associated protein 1 light chain 3 alpha (LC3A) and Microtubule-associated protein 1 light chain 3 beta (LC3B) Antibody Duo |
|---|---|
| Highlight | Related products: LC3 antibodies; LC3 Duos / Panels; |
Specific References
Integrinβ3 Mediates the Protective Effect of Soluble Receptor for Advanced Glycation End-products During Myocardial Ischemia/Reperfusion
ARG55799: WB / Mouse
Redd1 protects against post‑infarction cardiac dysfunction by targeting apoptosis and autophagy.
ARG55799: WB, ICC/IF / Mouse
Essential role of Bone morphogenetic protein 15 in porcine ovarian and follicular development and ovulation.
ARG55799: IHC-P / Pig
Bone Morphogenetic Protein 15 Knockdown Inhibits Porcine Ovarian Follicular Development and Ovulation.
ARG55799: IHC-P / Pig
Role of Autophagy in Acquired Cholesteatoma.
ARG51300, ARG55799: WB, IHC-P / Human
