ARG30263
Mitochondrial fission Antibody Duo (Drp1, BAX)
Publication5
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG55200 | anti-DNM1L / DRP1 antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG65612 | anti-Bax antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
Overview
| Product Description | Mitochondria routinely undergo fission and fusion events that maintain a dynamic reticular network. Dynamin-1-like protein (DNM1L), also known as Drp1, is a GTPase that fundamentally regulates mitochondrial fission. In response to many apoptotic stimuli, oligomerization of Bax is essential for mitochondrial outer membrane permeabilization and the ensuing release of cytochrome c. These events are accompanied by mitochondrial fission that require Drp1. This antibody duo provides useful tool for the study of the mechanism of Bax oligomerization in apoptosis and other biological processes. Montessuit et al. (2010) Cell (142): 889-901 |
|---|---|
| Target Name | Mitochondrial fission |
| Alternate Names | Mitochondrial fission antibody; DNM1L / DRP1 antibody; Bax antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Specific References
Cobalt protoporphyrin promotes human keratinocyte migration under hyperglycemic conditions
ARG65612: WB / Human
Preclinical Therapeutic Assessment of a New Chemotherapeutics [Dichloro(4,4'-Bis(2,2,3,3-Tetrafluoropropoxy) Methyl)-2,2'-Bipryridine) Platinum] in an Orthotopic Patient-Derived Xenograft Model of Triple-Negative Breast Cancers
ARG65612: WB / Human
Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling
ARG65612: WB / Human
Multi-omics analysis of pathological changes in the amygdala of rats subjected to chronic restraint stress.
ARG65612: WB / Rat
A LY-15, a novel cyclic pentapeptide that inhibits B16 cell proliferation and migration and induces cell apoptosis
ARG65612: WB / Mouse
