ARG30203
Phospho FAK Antibody Panel
Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
Publication1
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51136 | anti-FAK antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG51706 | anti-FAK phospho (Tyr397) antibody | Rabbit pAb | Hu, Ms, Rat | IHC-P, WB | 50 μl |
| ARG51831 | anti-FAK phospho (Tyr576 / Tyr577) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, WB | 50 μl |
| ARG51624 | anti-FAK phospho (Tyr925) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, WB | 50 μl |
| ARG65351 | Goat anti-Rabbit IgG antibody (HRP) | Goat pAb | Rb | ELISA, IHC-P, WB | 50 μl |
Overview
| Product Description | Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival. Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ. Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK. Schaller, M.D. et al. (1994) Mol Cell Biol 14, 1680-8. Cobb, B.S. et al. (1994) Mol Cell Biol 14, 147-55. Parsons, J.T. et al. (2000) Oncogene 19, 5606-13. Schlaepfer, D.D. et al. (1994) Nature 372, 786-791. |
|---|---|
| Target Name | FAK |
| Alternate Names | Phospho FAK antibody; Phospho Focal adhesion kinase antibody; FAK antibody; FAK phospho (Tyr925) antibody; FAK phospho (Tyr397) antibody; FAK phospho (Tyr576 / Tyr577) antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho Focal adhesion kinase (FAK) Antibody Panel |
|---|---|
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody |
Specific References
Probing the Expression of ASAP1 and FAK in nonsmall cell lung cancer and their clinicopathological significance
ARG51136: IHC-P / Human
