The first step in O-linked oligosaccharide synthesis is adding a N-acetylgalactosamine to serine or threonine resulting in the formation of the Tn antigen and Tn antigen can be proceed along different pathways through different glycosylation processes. The additional sialic acid by an α2,6-sialyltransferase forms the sialosyl-Tn antigen (SAα2,6GalNAcα-O-Ser/Thr), moreover, the sialosyl-Tn antigen might not apparently undergo further glycosylation. Both antigens have been shown previously to be highly sensitive and specific markers of various cancer types including colorectal cancer.

The abnormal protein glycosylation might associated with human cancer and the identification of protein glycoforms might be cancer biomarkers and therapeutic targets. In addition, the Tn antigen is also expressed by the protein gp120 of the human immunodeficiency virus (HIV), and in a wide range of helminth parasites.

arigo provides a Tn antigen antibody Duos, ARG30015, including antibodies reacting Tn antigen and Sialosyl-Tn antigen for users to study the potentially glycol-structure of the target protein in cancer or infectious area and it might be useful to findout the biomarker and therapeutic agent.