ARG44337
anti-MCF2 antibody
anti-MCF2 antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal recognizes MCF2 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MCF2 |
| Immunogen | Recombinant fusion protein of human MCF2(aa sequence 872-1001) |
| Conjugation | Un-conjugated |
| Alternate Names | MCF2; MCF.2 Cell Line Derived Transforming Sequence; DBL; ARHGEF21; Oncogene MCF2 (Oncogene DBL); Proto-Oncogene MCF-2; Proto-Oncogene DBL |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS (pH 7.3) and 0.01% Sodium azide. |
| Preservative | 0.01% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MCF2 |
| Gene Full Name | MCF.2 Cell Line Derived Transforming Sequence |
| Background | The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity. |
| Function | Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42. |
| Cellular Localization | Cytoplasm, Membrane |
| Calculated MW | 108 kDa |
| PTM | Phosphoprotein |
Images (1) Click the Picture to Zoom In
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ARG44337 anti-MCF2 antibody WB image
Western blot: HT-29 stained with ARG44337 anti-MCF2 antibody at 1:3000 dilution.
