ARG30145
Intermediate Neurofilament Antibody Panel (NF-L, NF-M,NF-H)
Controls and Markers antibody; Developmental Biology antibody; Immune System antibody; Neuroscience antibody; Signaling Transduction antibody
Publication1
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG52348 | anti-Neurofilament NF-L antibody [DA2] | Mouse mAb | Hu, Ms, Rat | FACS, ICC/IF, IHC-P, IHC-Fr, WB | 50 μl |
| ARG52351 | anti-Neurofilament NF-M antibody | Chicken pAb | Ms, Rat | ICC/IF, IHC-Fr, WB | 50 μl |
| ARG52347 | anti-Neurofilament NF-H antibody | Chicken pAb | Cow, Ms, Rat | ICC/IF, IHC-Fr, WB | 50 μl |
| ARG65350 | Goat anti-Mouse IgG antibody (HRP) | Goat pAb | Ms | ELISA, IHC-P, WB | 50 μl |
Overview
| Product Description | Neurofilaments are the major intermediate filaments found in neurons and consist of light (NFL), medium (NFM), and heavy (NFH) subunits. It appears that the essence of this assembly process is the heterotetrameric unit, which exists in two forms: NFL-NFM and NFL-NFH. Tetramer pairs form protofilaments and eight protofilaments constitute the final 10 nm intermediate filament. NFL is essential for the correct assembly of neurofilaments and maintenance of axonal calibre and NFM not only forms cross-bridges, stabilizing the filament network, but also helps in longitudinal extension. NFH also forms cross-bridges and may interact with micro-tubules and other cytoskeletal elements. Neurofilament accumulations are found in several human neurological diseases. These include ALS, Lewy bodies in Parkinson’s disease and some dementias (neurofilaments are a component of the Lewy body along with a-synuclein), Alzheimer’s disease, progressive supranuclear palsy, Charcot-Marie-Tooth disease, diabetic neuropathy, and giant axonal neuropathy. |
|---|---|
| Target Name | Intermediate Neurofilament |
| Alternate Names | Intermediate Neurofilament antibody; Neurofilament NF-H antibody; Neurofilament NF-L antibody; Neurofilament NF-M antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Antibody Panel for Intermediate Neurofilament (NF-L, NF-M,NF-H) |
|---|---|
| Research Area | Controls and Markers antibody; Developmental Biology antibody; Immune System antibody; Neuroscience antibody; Signaling Transduction antibody |
Specific References
KDF1 Promoted Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells through Activating STAT3 and AKT Pathway
ARG65350: WB /
