ARG30309

Polycomb Complexes Antibody Panel (H3K27me3, EZH2, Ring1A, RNF2)

Component

Cat No Component Name Host clonality Reactivity Application Package
ARG54703 anti-EZH2 antibody Rabbit pAb Hu, Ms FACS, ICC/IF, IHC, WB 50 μl
ARG63505 anti-RNF2 / RING1B / BAP1 antibody Goat pAb Hu WB 50 μg
ARG51437 anti-Ring1A antibody Rabbit pAb Hu, Ms, Rat WB 50 μl
ARG51851 anti-Histone H3 trimethyl (Lys27) antibody Rabbit pAb Hu, Ms, Rat WB, IHC-P, ICC/IF 50 μl
ARG65351 Goat anti-Rabbit IgG antibody (HRP) Goat pAb Rb ELISA, IHC-P, WB 50 μl
ARG65352 Donkey anti-Goat IgG antibody (HRP) Donkey pAb Goat ELISA, IHC, WB 50 μl

Overview

Product Description Polycomb-group (PcG) genes encode chromatin proteins involved in stable and heritable transcriptional silencing. PcG proteins participate in distinct multimeric complexes that deposit, or bind to, specific histone modifications (e.g., H3K27me3) to prevent gene activation and maintain repressed chromatin domains. Ezh2, Ring1A and Ring1B are core components of the mammalian Polycomb system, which regulates cell differentiation during embryonic development and tissue maintenance during adult life.

Grossniklaus and Paro. Cold Spring Harb Perspect Biol 3:11 (2014)
Rajasekhar and Begemann. Stem Cells 25: 2498-2510 (2007)
Chen et al. Am J Transl Res: 4: 364-75 (2012)
Target Name Polycomb Complexes
Alternate Names Polycomb Complexes antibody; Ring1A antibody; Histone H3 trimethyl (Lys27) antibody; EZH2 antibody; RNF2 / RING1B / BAP1 antibody

Properties

Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.